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Using a Microstructure-Property Approach to 'De-Risk' Pharmaceutical Formulations

Date: Thursday, April 11, 2013
Time: 9:00 AM EDT / 1:00 PM GMT
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Pharmaceutical formulation is a complex process that is full of risk. The interactions among ingredients can affect product quality. It is essential to understand the materials science principles behind each constituent ingredient and how they interact to ensure that risk is controlled and quality optimized.

In this program you will:
  • Review key formulation risks and how they can be controlled at the particulate level
  • Examine excipient functionality
  • Gain a better understanding of how 3D visualization and other techniques can be used to better understand material structure at a microscopic level
  • Understand how each constituent contributes to the tablet breakup process, to ensure the best release rate and uptake
  • See how modern techniques and data can be used to apply quality-by-design (QbD) approaches to formulation
  • Better grasp the relationships among structure, property, and performance

Paul A. Trusty, Technical Director, Solid Dosage Forms, GSK
Paul A. Trusty is a Technical Director, Solid Dosage Forms, for GSK. He is responsible for global technical support throughout the value chain, from new product development to scale-up, tech transfer, CMC registration, and product launch. He previously worked at Unilever. He has a PhD in materials science from the University of Surrey and undergraduate and graduate degrees in the subject from the University of Sunderland.

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